TRAIN Coordinator and Lead PI, Endre Kiss Toth was recently featured on local TV and Radio talking about a recent article in Science Advances that focuses on the Tribbles protein TRIB 1 and its contribution to the development of cardiovascular disease. The collaborative study, which involved the University of Leicester and scientists from Hungary and the US, suggest that inhibiting TRIB1 in macrophages could be a viable therapeutic target in treating cardiovascular disease. The research provides the long awaited ‘missing link’ that highlights the importance of cell-specific expression in cardiovascular disease. Although the work did not fall under the TRAIN programme, it points the way towards the kind of role that other TRIB proteins may have in chronic diseases and the pathways that the TRAIN programme is trying to elucidate.
Further details can be found on the University of Sheffield News Pages